Investigation of the effect of male cholestasis on the epigenome of sperm and the impact on the health of children of men with cholestasis

Awarded to King's College London

Professor Catherine Williamson, Women’s Health, King’s College London

The total grant awarded is £25,000

Duration of award: 17 June 2016 to 10 April 2018

Award details: "Investigation of the effect of male cholestasis on the epigenome of sperm and the impact on the health of children of men with cholestasis."

Summary

 ‘Aetiology and identification of subpopulations of PSC’ and ‘Treatment’. It will establish whether men with PSC have altered sperm, and aims to establish whether the observed alterations are reduced or prevented in those treated with ursodeoxycholic acid. Similarly, it will investigate whether cholestasis when fathering a child results in the children having an increased risk of having metabolic disease in later life (and whether this is less likely if the father was treated with ursodeoxycholic acid).

 

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