Dr Williamson - PIP-C Study
Investigation of the effect of male cholestasis on the epigenome of sperm and the impact on the health of children of men with cholestasis
Awarded to King's College London
Professor Catherine Williamson, Women’s Health, King’s College London
The total grant awarded is £25,000
Duration of award: 17 June 2016 to 31 August 2023 (extended due to COVID)
Award details: Investigation of the effect of male cholestasis on the epigenome of sperm and the impact on the health of children of men with cholestasis.
Aims to address unanswered questions around ‘Aetiology and identification of subpopulations of PSC’ and ‘Treatment’. It will establish whether men with PSC have altered sperm, and aims to establish whether the observed alterations are reduced or prevented in those treated with ursodeoxycholic acid. Similarly, it will investigate whether cholestasis when fathering a child results in the children having an increased risk of having metabolic disease in later life (and whether this is less likely if the father was treated with ursodeoxycholic acid).
(This study is recruiting - find out more)