Use of Animals Policy
PSC Support follows the AMRC principles in the use of Animals in Research
PSC Support appreciates that research using animals plays an important role in the research process and we support the principle of using animals when it is necessary
- to advance the understanding of primary sclerosing cholangitis and associated conditions.
- to develop treatment when there is no alternative that can be used to find out the same information without using animals.
PSC Support will only fund research involving live animals when this is essential to the outcome of the research, there is no alternative method of obtaining the data, and when pain and distress to animals is minimised.
We use expert peer review to ensure that we fund only high quality research where the benefits to human health outweigh any harm to animals. The use of animals must be fully justified in all applications for research grants.
PSC Support requires that all experiments should be carried out with due concern for the welfare of the animals, and using the minimum number necessary to provide clear data in well-designed experiments.
Individuals working on experiments using animals must have a personal licence and the institution must also have an establishment licence.
High standards of animal welfare are important. These both minimise discomfort for the animals involved and enable researchers to get reliable results. We only fund research which complies with the law and support the principle of the 3Rs to refine, reduce and replace the use of animals in research:
- Replace the use of animals with alternative techniques, or avoid the use of animals altogether
- Refine the way experiments are carried out, to make sure animals suffer as little as possible. This includes better housing and improvements to procedures which minimise pain and suffering and/or improve animal welfare.
- Reduce the number of animals used to a minimum by seeking ways to find out information from fewer animals or more information from the same number of animals.
PSC Support accepts that not all of the public can accept research using animals.
Our Standard Terms and Conditions for grant awards specifically refer to the ethical use of animals. Our requirements are that:
1.1. A project involving the use of animals may not be commenced in the absence of Home Office licences covering all relevant institutions the researchers and the research activity. Acceptance of an award constitutes confirmation that any necessary consent including Home Office approval under the Animals (Scientific Procedures) Act 1986 or other relevant legislation has been obtained. Grant holders are expected to adopt procedures and techniques which minimise the use of animals.
1.2. Research using animals plays an important role in the research process and PSC SUPPORT supports the principle of using animals when it is necessary to advance the understanding of Primary Sclerosing Cholangitis and associated conditions to develop treatment when there is no alternative that can be used to find out the same information without using animals. Expert peer review is used to ensure that we fund only high quality research where the benefits to human health outweigh any harm to animals. PSC SUPPORT supports the Association of Medical Research Charities statement on animal research.
1.3. All experimental programmes supported by PSC Support must only use animals were there are no alternatives.
1.4. Experiments using animals funded by the PSC Support must:
1.4.1. use the simplest possible, or least sentient, species of animal
1.4.2. ensure that distress and suffering are avoided wherever possible
1.4.3. employ an appropriate design and use the minimum number of animals consistent with ensuring that the scientific objectives will be met
1.5. See the NC3Rs website for further information and guidance.
1.6. All grant holders using animals must implement the principles in the cross-funder guidance Responsibility in the Use of Animals in Bioscience Research.
1.7. Grant holders using non-human primates must comply with the NC3Rs guidelines Primate Accommodation, Care and Use.
1.8. Grant holders should make use of the ARRIVE guidelines when designing their experiments, and ensure that they report animal-based studies in accordance with the ARRIVE guidelines as far as possible, taking into account the specific editorial policies of the journal concerned.