Paternally Inherited Phenotypes in Cholestasis Study - (PIP-C)
ClinicalTrials.gov Identifier: NCT03337074
This study is investigating whether cholestatic liver diseases such as PSC can impact the structure and function of sperm. This is important because changes to the sperm can affect the health of the children conceived from those sperm. In this study, the health of 16 – 25 year-old children of fathers with cholestatic liver diseases such as PSC is also being investigated.
The study has 2 arms, the Sperm Epigenome arm and the Outcomes arm. Each participant can decide if they are eligible/would like to take part in one or in both arms of the study.
In the Sperm Epigenome arm, the structure and function of sperm from men with PSC and other cholestatic liver disorders will be investigated and compared to the structure and function of sperm from healthy men.
In the Outcomes arm, basic health parameters in fathers who had PSC or another cholestatic liver disease either before or after their child was conceived will be investigated, as well as basic health parameters in their child when they are aged between 16 and 25 years old.
UK Locations
- King's College Hospital, London
- Guy's Hospital NHS Foundation Trust, London
- Queen Elizabeth Hospital, Birmingham
Contact information
Chief Investigator: Professor Catherine Williamson (catherine.williamson@kcl.ac.uk)
Trial Manager: Sonia Serrano (Sonia.Serrano@gstt.nhs.uk)
Find out more
On hold until further notice because of COVID-19