Symptoms Symptom assessment and management in PSC Symptom management in PSC (Dr James Ferguson) Dr Ferguson talks about managing the symptoms you might experience with PSC. In this section: Fatigue Fatigue is the most commonly reported symptom in people with PSC. Read More Itch What causes itch in PSC and how can it be managed? Read More Pain Pain is a common symptom in PSC and affects quality of life. Read More Depression and Anxiety The uncertainty associated with the unpredictable nature of PSC can understandably lead to feelings of anxiety and low mood. Read More Want to know more? Receive regular info, tips and news on all things PSC Donate We rely on charitable donations to make our vital work possible Get a PSC Alert Card Emergency cholangitis information for you and your doctors.