Autoimmune hepatitis (AIH)
AIH is an autoimmune liver disease where the body’s immune system attacks its own liver cells (hepatocytes), causing inflammation and damage. 6.2%-14% of people with PSC also have AIH 2,46. PSC and AIH can occur together or develop at different times (AIH is often first), usually in young people under 25 years of age 1,47.There is no consensus on the name for this condition in children and young people and you may see it referred to as:
- primary sclerosing cholangitis–autoimmune hepatitis overlap syndrome,
- primary sclerosing cholangitis with features of autoimmune hepatitis, and
- autoimmune sclerosing cholangitis 48.
Although PSC and AIH have overlapping features, they are separate conditions and are therefore treated separately 49.