Fatigue is the most commonly reported symptom in people with PSC and affects quality of life.
Fatigue in PSC does not relate to severity of the liver disease 115.
We all experience tiredness at times, which can be relieved by sleep and rest. Fatigue is overwhelming tiredness that isn't relieved by sleep or rest.
The exact mechanism by which fatigue is caused in PSC is unclear 115 although studies have found that fatigue in PSC can be related to autonomic dysfunction 116, psychological distress and physical pain (rather than associated IBD or PSC severity) 117 and depression 115.
People with PSC often report that they have disturbed sleep patterns and insomnia, all of which can contribute to the feeling of tiredness and fatigue.
What does fatigue feel like?
How does fatigue impact day to day life? Is fatigue the same as being tired?
What does brain fog feel like?
Some people also describe 'brain fog' when talking about PSC.