Guidelines for the diagnosis and management of PSC
What are Guidelines?
When medical teams care for patients, they often refer to Guidelines. Guidelines are a set of recommendations on the diagnosis and management of a disease that are made by experts, based on evidence (or expert consensus if there is not enough evidence to support the recommendation). The guidelines are referred to in a number of ways, including: Clinical Practice Guidelines, Practice Guideline and Clinical Guideline.
Is there a Guideline for PSC?
There are several regional guidelines for PSC, so depending on where you live, you might receive slightly different care.
The guidelines are broadly the same, with differences mainly based on individual healthcare systems.
PSC Support is currently working with European PSC experts to update the 2009 EASL Clinical Practice Guidelines.
UK PSC Guidelines
The guidelines for the diagnosis and management of PSC in the UK were published in 2019 and officially launched at the UK-PSC Study Day by Professor Douglas Thorburn.
They were written by UK-PSC with PSC Support, and are endorsed by the British Society of Gastroenterology. We incorporated the guideline recommendations into the 'Your Medical Care' section of our website as soon as they were published.
Refer to our ‘Questions for Your Doctor’ page to help guide your routine PSC hospital appointments.
Regional PSC Guidelines
- 2019 British Society of Gastroenterology and UK-PSC Guidelines.
- 2009 EASL Clinical Practice Guidelines: Management of cholestatic liver diseases.
Strength and Quality of Recommendations
What does this mean? Each recommendation is rated by a 'strength of recommendation' and a 'quality of evidence' grading. Because PSC is complex and still poorly understood in some ways, some of the evidence used is 'low quality', and that's often because the evidence is simply not available. When this is the case, the recommendation is based on the majority consensus of expert opinion.
Huge thanks to Professor Douglas Thorburn for reviewing PSC Support's interpretation of each recommendation. 6 November 2019